Cialis Professional: Highlights, Doses, Contraindications
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Cialis Professional is a new reformulated and chemically enhanced erectile dysfunction medication that ensures a perfect strength and entire satisfaction to any ED sufferer. It has much in common with an original Cialis medication that was released over a decade ago, yet still many of its characteristics are more beneficial and add value to every sexual experience, even in patients where impotence is provoked by a serious health condition.
Cialis Professional and FDA Approval
The diagnosis of erectile dysfunction (in specific literature, abbreviated as ED) is established when a man is unable to achieve penile hardness sufficient for penetration and conducting a sexual act.
Unstable erection is something that the majority of men would encounter at some point throughout their sexually active years (one of the recent studies re-evaluating the picture of ED epidemics can be found here). According to the data shared on the official NCBI website, ED continues to be considered a condition closely related to age and ageing, with significant prevalence of decline in sexual function by the age of 70. This report shows that in men in the subset of 40-70 years of age, ED of varied degree was diagnosed in 52% of cases.
Although not being a condition putting an individual’s health at risk, ED has its deleterious toll on a person’s life, both organically and psychologically. Erectile hardness has always been one of the important components of virility, alongside with penile size. It is not difficult to imagine that a disrupted ability to achieve or maintain erection has a depressing effect on a man in a multidimensional way that incorporates private, relational and social repercussions.
Since late 90s, Viagra (sildenafil), the first vasodilatory substance designed to treat the symptoms of ED in a non-invasive way, made its entrance into the market place. Cialis (tadalafil) was contributed a few years later, in 2003, and offered an improved longer-acting formula unaffected by simultaneous intake of alcohol or meals with high content of fat. FDA approved tadalafil (Cialis) in November 2003 (you can find specific documentation reflecting different aspects of Cialis FDA approval here). Cialis Professional appeared a few years later, after the expiration of the original patent, when the substance (tadalafil) became available for generic production.
Cialis Professional is an oral pill with maximally allowed dose of tadalafil, available in form of Cialis Professional 20mg and 40mg. The new version of tadalafil has gained popularity over the first weeks of its existence and has firmly secured its positions among customer choice drugs for ED thanks to the following features:
- dependable quality
- low price
- highly impactful dose
A pill of Cialis Professional is taken 20 to 30 minutes before a sexual activity is planned. The drug will remove the symptoms of ED for 36 hours, which is exactly it is sometimes called “weekend pill”.
The side effects of Cialis Professional are synonymous to those of the brand drug, and are scarce, mild and fleeting in their nature; they also tend to disappear with continued use of the drug as the taker’s body adjusts to the effects of tadalafil (the response towards the substance, meaning the health results, improves, too).
Clinical Trials
During a study that involved 443 volunteers aged above 50 and lasted 30 days, men with mild to severe ED were given Cialis Professional pills in a double-blind, placebo-controlled testing of tadalafil efficacy. The volunteers were grouped into subsets based on gravity of their condition. The research showed that the mean of 81.7% of men were able to achieve penile hardness against 16% against placebo efficiency, subject to variation based on ED severity (79% for full ED group and 83% for mild ED).
Placebo and Cialis
Compared to results achieved in placebo controlled group, Cialis PRO helped takers achieve meaningful erectile improvement that allowed them to engage sexually without experiencing issues with penile hardness typical for their condition.
Multiple studies have confirmed efficiency, safety and simplicity of use of Cialis Professional. The drug can be used by a broad spectrum of populations, in particular, by men suffering from full ED and senior citizens, without health risks. Produced by reliable manufacturers of generic tadalafil and purchased from a reputable online drugstore, Cialis Professional is one of the most popular solutions for ED among men of different age groups and across economical strata.
What’s the Success Rate of Cialis Professional?
Statistically, 8.7 men in 10 report ultimate satisfaction with the health results they were able to achieve with Cialis Professional, with the following measurable benefits of the drug illuminated by researchers:
- Improvement in penile hardness 97.8%
- Boost in stamina 87.1%
- Shortened recovery after ejaculation 79%
- Improved self-image 94.4%
- Improved control over sexual act duration 73.2%
- General satisfaction with sexual activity 98%
Main Highlights
- Cialis Professional provides symptomatic treatment for ED, but does not offer full recovery. The drug is taken directly before sexual activity. For scheduled therapy course, Cialis Daily is used in the dose of 2.5mg to 5mg.
- Cialis Professional is prescribed to men aged 18 to 65 suffering from ED or BPH; the drug is not intended for the use in women and children.
- Cialis PRO is neither a contraceptive nor an aphrodisiac, it does not protect from sexually transmitted diseases and does not affect user’s libido.
- There are side effects and contraindications to be observed. Cialis Professional is a prescription drug whose use should be approved by a healthcare specialist.
- Cialis Professional addresses performance anxiety, relieving it thanks to self-confidence that user regains with restored erectile ability.
What are the benefits?
Compared to other ED drugs for peroral administration, Cialis Professional offers the following benefits:
- Heavy-duty action lasting up to 48 hours as opposed to 4 hours for other drugs
- Faster onset – 20 minutes contrasted to 60 minutes
- Highly impactful dose of tadalafil 40mg
- Excellent success rates in men with mild to full ED
- Compatibility with alcohol
- Compatibility with any type of food (save for grapefruits)
Fast Onset
Cialis Professional is a drug that works fast and works under circumstances in which the effects of other PDE5 inhibitors get severely compromised. The action of Cialis Professional sets in within 20 to 30 minutes (subject to variations depending to individual response)
Effects that last… and last!
Cialis Professional is synonymous with heavy-duty action. Its effects last from 36 hours manifested in manufacturer’s guidelines to 48 hours of drug activity in practice, as reported by actual users. The reputation of the “weekend pill” precedes it!
Can take on full ED
Cialis Professional is one of the few drugs out there whose efficiency is experienced to the fullest by patients suffering from full ED – that is, complete inability to achieve any degree of penile hardness. The dose of tadalafil contained in this generic Cialis tablet is sufficient to restore vascular circulation in the penis and enable a user with severe ED degree to conduct a satisfactory sexual act.
Years of safe use in patients of all age groups
The side effects of Cialis Professional have been all very well studied over the years that the drug has been on the market, and the drug was found to be safe for long-term use. In fact, the longer you take the medication, the fewer adverse event you experience, without a decrease in health results. This official report on tadalafil safety sums up the data on the drug’s effects in short and long term.
How Does Cialis PRO Work?
Cialis PRO is a vasodilatory agent, which means that it affects walls of the blood vessels found in the corpora cavernosa of the penis, so that maximal absorption and retention of blood is secured. This mechanism operates thanks to the ability of tadalafil to foster Nitric Oxide (NO), a substance that is released in healthy men during either reflex or psychogenic erection (“reflex” erection can be defined as a reaction to touch, while “psychogenic” erection is triggered by such erotic stimuli as fantasizing, visual perception, etc.). NO is released when tadalafil inhibits an enzyme called phosphodiesterase type 5 (PDE5); hence the name of the entire class of drugs Cialis Professional belongs to – PDE5 inhibitors.
As can be seen from the mechanism described above, Cialis Professional fully mimics the natural workings taking place in male body during all of the phases of sexual arousal. After ejaculation, the penis returns to its relaxed state. If the effects of the drug have not yet worn out, another erection is possible given that the taker is exposed to sufficient sexual stimulation.
We reiterate that Cialis Professional is not an aphrodisiac agent; it does not affect sexual appetite of user. In the absence of sexually arousing circumstances, erection will not occur.
Cialis Professional can address erectile problems of mild, moderate and severe form. It also can regenerate sexual health in individuals with organic and psychogenic ED alike, as long as vascular health of the patient is not compromised (for instance, if the onset of ED is conditioned by sickle cell disease).
Dosage Strengths and Forms
Cialis Professional is available in forms of capsules containing tadalafil 20mg and tadalafil 40mg. It is mandatory that a healthcare prescriber appoints the maximally allowed dose for every individual case. Physical examination should be done and, in some cases, blood panels should be run to rule out conditions that would make the use of the drug potentially unsafe or require a dose reduction. Do not take more than 1 recommended dose of Cialis Professional during 24 hours.
Taking Instructions
Cialis Professional is supposed to be taken 30 minutes before planned sexual activity. The onset of its effects commonly occurs 20 minutes after the intake. The drug is only taken as needed. Take a pill with a sufficient amount of water (ca 1 glass), without chewing or crushing the capsule in your mouth.
Cialis PRO can be taken either after a meal or on an empty stomach. Taking the drug after a meal will decrease the risk of adverse events. The effects of the drug are not compromised by simultaneous intake of fatty foods and alcohol.
Contraindications
Tadalafil has a registry of contraindications and is therefore not administered to certain subsets of patients. It is up to a certified healthcare provider to establish if an individual is eligible for treatment with Cialis Professional. Before you buy Cialis, Canadian Pharmacy, seek medical consultation in order to rule out any possible contraindication that would make the use of tadalafil based drugs potentially risky for your individual health condition, age, medical history, drug tolerance, etc.
The following categories of patients should refrain from Cialis PRO therapy:
- Patients suffering from kidney diseases;
- Men with liver disorders;
- Individuals with heart disease or a history of stroke experienced within the past 6 months;
- Men with sickle cell anemia;
- Men suffering from penile deformity known as Peyronie’s disease;
- Individuals with unstable blood pressure (hypertensive and hypotensive conditions alike);
- Individuals who are not recommended to engage in sexual activities;
- Men with blood cell diseases;
- Patients with history of Priapism (prolonged or painful erections).
Cialis Professional 20mg Recommendations
Commonly experienced side effects of Cialis Professional are:
- Headache
- Facial flushing
- Nasal congestion
- Upset stomach / dyspepsia
- Back pain
Most of Cialis Professional side effects are short-lived and well tolerated. However, there are signs that the use of tadalafil is unsafe in your case based on individual reactions and intolerances.
You should discontinue the use of the drug and seek immediate medical attention:
- Vision disturbances
- Heart palpitations, increased heart rate
- Rash and severe allergic reactions
- Pain in the chest
- Pain in the jaw
- Pain in the arm
- Erection that is painful or does not subside for 4+ hours
- Severe drop or spike in blood pressure
- Dizziness
- Sudden onset of fatigue
Special Notices
- Grapefruit and grapefruit juice: avoid having grapefruits or grapefruit juice within 2 hours from taking Cialis PRO; grapefruits inhibit the enzyme responsible for excreting tadalafil, which can lead to intoxication.
- Alcohol: while the effects of Cialis Professional (its pharmacokinetics) are not influenced by alcohol, it is recommended to avoid that letter in order not to further compromise erectile function. Alcohol has a deleterious effect on the ability to perform sexually. Besides that, alcohol in combination with tadalafil augments the likelihood of side events.
- Painful or prolonged erections: although quite rare as a side effect of Cialis PRO, prolonged or painful erection may occur. If your erection does not subside in 4 hours, seek medical help immediately; failure to do so may result in irreversible damage to penile tissues.
- STDs: Cialis Professional is not a contraceptive solution, and it does not prevent spreading of STDs.
Other Meds and Cialis PRO 20mg: What Combinations Are Risky?
Cialis Professional should not be taken in combination with drugs that cause drop in blood pressure, such as nitrate containing medications and alpha-blockers (eg, Prazosin and Terazosin, Doxazosin and Tamsulosin, Silodosin and Alfuzosin), “poppers” (recreationally used drug substances).
Anti-fungal drugs for peroral use: concomitant use of drugs against fungal infections like Itraconazole and Ketoconazole can increase such side effects of Cialis PRO as lightheadedness, pre-syncopal and syncopal states (dizziness, fainting) and prolonged erections.
Drugs against PAH: simultaneous use of Cialis Professional with drugs of this class may result in increased risk and intensity of the drug’s side effects, based on similar vasodilatory action produced by the drugs of both classes.
The same holds true for HIV drugs like Ritonavir or Liponavir: their concomitant use with Cialis PRO can cause high concentration of tadalafil in blood plasma, causing hypertensive crises and vision disturbances.
Cialis Professional comes into interaction with certain antibiotics: Telithromycin, Clarithromycin and Erythromycin increase toxicity of tadalafil, while others, such as Rifampin, inhibit its concentration in blood.
Cialis Professional and Diabetes: What Should Be Expected?
Recent recommendations for type 2 diabetes indicate that PDE5 inhibitors like Cialis Professional have demonstrated efficacy in erectile dysfunction in diabetic patients. Cialis PRO may be offered as a first-line treatment except in patients with active coronary artery disease or nitrate-treated patients.
If an Ciails PRO does not yield meaningful results in a diabetic patient, you should:
- check if the prescription has been correctly accompanied by a global management of the sexual disorder or if it has replaced it;
- check for lack of testosterone deficiency;
- evaluate the impact of possible “cardiophobia” of the patient or partner;
- check if the side effects are not dominant, masking the therapeutic effect;
advise the patient to do several tests before concluding that they have failed.
Strategies in case of failure:
- try to improve communication within the couple;
- eliminate the causes of work and family stress;
- correct hypotestosteronemia;
- reassure about side effects and tachyphylaxis;
- adjust the dosage;
- change of PDE5 inhibitor
- consider other treatments
Cialis Professional and Heart Patients: Possible Dangers?
Cialis Professional has shown a beneficial effect on lowering blood pressure and improving endothelial function. It has also been established that the prescription of Cialis Professional is accompanied by an improvement in coronary reserve and improves the ischemic threshold in coronary patients. The safety profile of Cialis Professional is excellent in this population and interactions with other drugs (beta-blockers, aspirin and statin) are minimal with the exception of nitrates.
The drug does not increase the risk of heart attack, stroke, or cardiovascular death. This has been demonstrated by meta-analyzes of randomized studies and post-marketing analyzes of several thousand patients. An important and fundamental question to ask is whether the treatment of erectile dysfunction by Cialis Professional can have a favorable impact on cardiovascular risk. After all, sildenafil has been developed for cardiovascular therapeutic purposes. Data is limited to answer this question. Nevertheless, a trend toward decreased cardiovascular mortality has been shown in a population of diabetic patients with asymptomatic coronary artery disease treated with Cialis Professional. The small number of patients, however, did not allow a definitive conclusion.
ED is common in patients with heart failure, yet there is still a fear in the medical community about the prescription of Cialis Professional. However, the scientific data support that tadalafil at a dose of 3×5 mg is accompanied by an increase in cardiac output during exercise and an improvement in the physical capacity of patients whose ejection fraction is severely impaired. It is interesting to note that these data were obtained in polytreated patients by definition, most of whom benefited from a treatment of heart failure associating a beta-blocker and an inhibitor of the conversion enzyme. The prescription of sildenafil in this population of patients is accompanied by an improvement in the quality of life and the treatment would also be responsible for a decrease in the number of hospitalizations.
One of the pathophysiological mechanisms by which Cialis Professional would be responsible for improving the patient’s clinical condition is that oxidative stress increases the expression of phosphodiestrase-5 in the defective myocardium. This has been demonstrated both in a mouse model and in humans. Cialis Professional is therefore an interesting therapeutic pathway in heart failure. However, it is necessary to qualify the subject and temper the enthusiasm since no randomized study has so far shown any benefits on mortality. Side effects related to the use of Cialis Professional in heart failure patients seem limited, although tolerance has not been evaluated in a very large number of patients.
Cialis Professional and blood pressure
ED affects 15 to 46% of hypertensive patients. Endothelial dysfunction is once again the pathophysiological basis of both diseases. In addition to high blood pressure, erectile dysfunction is also a common complication of antihypertensive therapy. Anti-hypertensive drugs associated with erectile dysfunction include diuretics, aldosterone antagonists, beta-blockers and central antihypertensives. In contrast, other commonly used classes, anti-calcium drugs, ACE inhibitors and angiotensin receptor blockers are rarely involved. It seems that PDE5 inhibitors can be prescribed safely in this subset of patients. This has been well demonstrated by studies and meta-analysis evaluating the effects of sildenafil and tadalafil in combination with one or more antihypertensives. The authors showed a low impact on blood pressure and no syncope or episode of orthostatic hypotension was deplored.