Cialis Soft Tabs: Applications, Benefits, Drug Interactions
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Cialis Soft Tabs is one of the most popular medications for men’s health. It should be noted that this drug became reputable due to the fact that it doesn’t require any food or alcohol rationing. Its application results in a considerable potency improvement. All necessary reactions in organism are stimulated by Cialis’s active substance tadalafil. Tadalafil is an effective selective phosphodiesterase type 5 inhibitor of cyclic guanosine monophosphate. When sexual arousal causes local release of nitrogen oxide, inhibiting of PDE5 by tadalafil leads to increase of cyclic guanosine monophosphate level in cavernous bodies of penis. This results in relaxation of unstriated muscles of arteries and blood flow to penis tissues causing erection. Tadalafil doesn’t take effect in case of absence of sexual stimulation.
PDE5 is enzyme found in unstriated muscles of a cavernous body, unstriated muscles of splanchnic vessels, skeletal muscles, thrombocytes, renal system, lungs and tentorium. Tadalafil’s impact on PDE5 is the most active than on other phosphodiesterase types. Tadalafil is as 10000 times as more efficient in regards to PDE5 than in regards to PDE1, PDE2, PDE4, and PDE7 which are located in heart, brain, blood vessels, liver, leukocytes, skeletal muscles and other organs. Tadalafil is as 10000 times as more active in blocking of PDE5 than PDE3 (enzyme located in heart and blood vessels). This selectiveness concerning PDE5 in comparison with PDE3 is of high importance, since PDE3 participates in contraction. Besides, tadalafil is as 700 times as more active in regards to PDE5 than in regards to PDE6 localized in retina. Tadalafil improves erection and possibility of performing of successful sexual intercourse. The medicine is effective within 36 hours. The effect occurs in 16 minutes after its intake in case of sexual arousal.
Tadalafil doesn’t cause changes in the level of testosterone, luteinized and follicle-stimulating hormones in blood plasma. There wasn’t any considerable influence on semen of men who took daily dose of tadalafil within the course of 6 months at placebo controlled trials.
Applications of Cialis Soft Tabs
Therapeutic indications:
- Low level of male libido, insufficient erection;
- Erectile dysfunction, impotency, prostatitis;
- Premature ejaculation;
- Impossibility of bright orgasm achievement;
- Absence of sexual arousal and desire;
- Low energy, lack of self-confidence, long-term depressions;
- Insufficient activity and endurance while sex.
Cialis Soft Tabs are produced in the form of white small tablets covered with slim film coat. The product should be dissolved, it doesn’t need to be chewed or swallowed. One blister contains 10 pills. They have a pleasant flavor and smell and are easily dissolved under the tongue.
The optimal dosage is one tablet (20mg) per day. It should be taken 15-20 minutes before sexual intercourse. Medical experts recommend applying Cialis Soft Tabs not only for one-time-use but within a treatment course. The duration of the course is not limited. Minimal daily dose is half a tablet (10mg of tadalafil). Patients suffering from cardiac or renal disorders are highly recommended reducing the dosage. It may be enlarged only after consultation by a specialist. Patients are able to have sexual intercourse any time within 36 hours after the intake in order to fix an optimal time of treatment response.
After taking a pill, it gets dissolved rapidly. The maximal concentration in blood plasma is achieved in average 2 hours after the intake. Speed and absorption degree of tadalafil do not depend on meal, therefore Cialis Soft Tabs may be taken regardless of food intake. Time of food acceptance (morning or evening) didn’t have any clinically significant effect on speed and absorption degree either.
The average volume of Cialis Soft Tabs distribution is around 63% showing that tadalafil is allocated in organism tissues. In therapeutic concentrations 94% of tadalafil is connected with proteins in blood plasma. Connection with proteins is not changed in case of renal system disorder.
Contraindications: Is Cialis Soft Tabs Right for Me?
Before purchasing Cialis Soft Tabs, make sure you do not have the following counter-indications:
- Ascertained enhanced sensitivity to tadalafil or any other substance constituting the drug;
- In case a patient takes any nitrates-containing medications;
- Patients suffering from cardiac, vascular, renal disorders;
- In case a patient has undergone heart or apoplectic attack, hypotony, hypertension, arrhythmia within the last six months;
- Low arterial blood pressure;
- Sexual organs deformation;
- Duodenal or gastric ulcer;
- Myeloma or priapism;
- Leukemia;
- Persons under 18 years of age.
Use with care
Since there are no data in regards to the patients suffering from hepatic decompensation, Cialis Soft Tabs should be taken with care by this group of patients. Also, patients taking Cialis Soft Tabs altogether with alpha adrenergic blocking agents (e.g. doxazosin) should be careful, since simultaneous intake of these two medicines may lead to symptomatic hypotension for some of the patients.
Health Effects and Benefits
Cialis Soft Tabs appeared at pharmaceutical market not so long ago and got itself noticed among consumers. The main component, tadalafil is a basis forming a combined action of all substances and leading to positive medical results. This medication-generic is successfully sold all around the world for erectile dysfunction treatment and erection improvement.
Cialis Soft Tabs is indicative for comprehensive approach to problems of erection and erectile dysfunction for men at any age group. This drug is effective for treatment on various stages of diseases and diverse manifestation rates including cases of psychophysiological disorders.
Advantages of Cialis Soft Tabs usage:
- Duration of medicine’s effect is 36 hours which is not achieved by taking any of the drug belonging to this group of inhibitors;
- Guaranteed erection in various cases of erectile disorders even in severe form;
- Even in case of strongly pronounced sexual arousal, erection quality is preserved even for the next day after the intake;
- The medicine’s cost is quite reasonable.
Cialis Soft Tabs is in the form of tablets for dissolving. This variant allows accelerating the onset time of the medicine and achieving improvement of sexual functioning. Positive effect rate enables to avoid the contact of the drug with stomach acid and alimentary system enzymes resulting in possibility to take Cialis Soft Tabs altogether with food and alcoholic drinks.
Possible Side Effects
- The most undesirable effects that may arise from Cialis Soft Tabs intake are headaches and dyspepsia (11 and 7% cases accordingly). Unfavorable events connected with tadalafil intake were generally insignificant or of average degree of manifestation, transient and reduced after continuation of drug’s intake.
- Other general side-effects are backache, myodynia, stiffness in nose and blushing.
- Seldom – palpebral oedema, ophthalmalgia, conjunctival hyperemia and vertigo.
- Very seldom – reactions of high sensitivity (including rashes, urticaria, facial oedema, Stevens–Johnson syndrome, and exfoliative dermatitis); hypotension (patients who have already taken antihypertensive agents); hypertension and syncope; stomachache and esophageal reflux; hyperhidrosis (excessive sweating); priapism and erection delay; blurred vision, non-arterial anteriorischemic optic neuropathy; retinal vein occlusion; sight disturbance.
- Myocardial infarction, sudden cardiogenic death, apoplectic attack, heartbeats and tachycardia appeared in patients who had had CvRF earlier. Anyway, it is impossible to determine whether these factors are directly connected with these risk factors, tadalafil, sexual arousal or their combination or not.
Overdose
In case of a one-time intake of tadalafil by healthy individuals in dosage up to 500mg and patients with erectile dysfunction (many times up to 100mg per day), the undesirable effects were the same as occurred in case of usage of much smaller doses. In case of overdose it is important to conduct a standard expectant treatment. During haemodialysis process tadalafil is normally not cleared.
Food and Drug Interactions
Cialis Soft Tabs and Alcohol
Thanks to the fact that the tablet is dissolved in mouth cavity and gets to organism in split form, manufacturers do not prohibit to take it with moderate amount of alcohol. Choose drinks with minimum percentage of alcohol. You may opt for wine, Champaign, low-alcoholic cocktails. It is not recommended taking more than 200 ml of alcohol with Cialis Soft Tabs per day.
According to clinical trials, tadalafil didn’t affect concentration of alcohol as well as alcohol didn’t affect concentration of tadalafil. High dosage of alcohol (0,7g/kg) with tadalafil didn’t cause statistically significant decrease of blood pressure average value. Some patients had postural vertigo and postural hypotension. The administration of tadalafil with lower dosages of alcohol (0,6 g/kg) didn’t cause hypotension, and vertigo occurred with the same frequency as it occurred while taking only alcohol.
Fat food combined with Cialis Soft Tabs
Cialis Soft Tabs is compatible with fat food. This combination doesn’t affect the efficiency of its action. Anyway, before you eat products the fatness of which surpasses 30%, it should be taken into account the causes of sex-related problems, such as:
- Incorrect or irregular ration;
- Eating of harmful products.
In order to avoid a backset, medical experts recommend eating healthy and high-fiber food: vegetables, fruit, whole grains.
Cialis Soft Tabs and interaction with other medicines
It is well known that tadalafil enhances hypotensive action of nitrates. This happens as a result of additive action of nitrates and tadalafil on metabolism of nitrogen oxide and cyclic guanosine monophosphate. Therefore, tadalafil usage in combination with nitrates is strictly forbidden.
Tadalafil has system vasolidatory characteristics and can enhance the action of anti-hypertensive drugs aimed at decrease of blood pressure level. Patients who took several anti-hypertensive drugs and were poorly controlled, had considerable drop of blood pressure. The overwhelming number of patients had the pressure drop not connected with hypotensive symptoms. Patients taking anti-hypertensive drugs in combination with tadalafil must be given special clinical recommendations.
There wasn’t observed any considerable drop of blood pressure in case of combination of tadalafil with selective alpha-adrenergic blocking agent, tamsulosin. In case of combined intake of tadalafil with alpha-adrenergic blocking agent, doxazosin (8mg per day) by healthy volunteers, there was observed an enhanced hypotensive action of doxazosin. Some patients felt vertiginous, but the cases of syncope were not registered. The lower doses of doxazosin were not studied.
Tadalafil doesn’t take clinically significant action on clearance of the medicines the metabolism of which is realized with participation of cytochrome isoenzyme P450. According to research studies is was shown that tadalafil doesn’t inhibit or induce isoenzymes CYP3A4, CYP2C19, CYP2E1, CYP1A2, CYP2C9, CYP2D6. Tadalafil doesn’t influence duration of bleeding, caused by acetylsalicylic acid.
List of Medicines the Combination with Which Is Dangerous
Combined intake of Cialis Soft Tabs with medicines containing nitrates may lead to severe hypotony which is dangerous in some cases. Avoid taking tadalafil with such medicines as pentaerythritol tetranitrate, nitroglycerin, isosorbide mononitrate, isosorbide dinitrate, tetranitrate. The level and toxic potential of Cialis Soft Tabs increases along with ritonavir (norvir), indinavir (crixivan), itraconasole (sporanox), ketoconazole (nizoral), erythromycin. Consult your attending doctor if you take urapidil, telithromycin, saquinavir, prazosin, phentolamine, phenoxybenzamine, nelfinavir, itraconasole, indinavir, erythromycin, doxazosin, clarithromycin, atazanavir, since the correction of tadalafil’s dose may be required.
Safety Note
Sexual activity has a potential risk for patients suffering from cardio-vascular diseases. Therefore, treatment of erectile dysfunction including Cialis Soft Tabs intake shouldn’t be conducted by men having those cardiac diseases where sexual activity is not recommended.
The potential risk of complications caused by sexual activity for patients suffering from cardio-vascular diseases should be taken into account:
- myocardial infarction within the last 90 days;
- unstable angina or angina occurring during sexual intercourse;
- second degree cardiac decompensation and higher according to NYHA within the last six months;
- uncontrolled disorders of cardiac rhythm, hypotony or uncontrolled arterial hypertension;
- apoplectic attack within the last six months.
Cialis Soft Tabs should be taken with care by patients with underlying risk for priapism (for example in case of sickle-cell anemia, erythroid myeloma, or leukemia) or by patients with anatomic deformation of penis (for instance in case of angulation, cavernosal fibrosis, or Peyronie’s disease).
The cases of priapism while taking PDE5 inhibitors including tadalafil were reported. Patients must be informed of the importance of immediate medical resource utilization in case of erection lasting four hours and more. Undue treatment of priapism will lead to damage of penis tissues resulting in long-term potency loss.
Like other PDE5 inhibitors, tadalafil has system vasolidatory characteristics which may cause transient blood pressure drop. Before prescribing Cialis Soft Tabs, a doctor should consider if a patient with any of cardio-vascular diseases may be adversely influenced because of vasolidatory effects.
Storage Requirements
Do not store above 30°С in original package. Keep out of reach of children. Expiration date: 3 years. Do not use Cialis Soft Tabs after expiration period.
The Full List of Ingredients
Active substance: tadalafil. Each tablet of the medicine contains 20mg of tadalafil.
Auxiliary substances: lactose monohydrate, croscarmellose sodium, hydroxypropyl cellulose, microcrystalline cellulose, lauryl sulfate sodium, stearate magnesium, colorant mixture Opadri II yellow.