Cialis Black 800 (Tadalafil): Applications, How To Use, Contraindications, Side Effects
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CONTENT
- Applications
- How To Use Cialis Black
- Contraindications: Is Cialis Black Right For Me?
- Health Effects And Benefits
- Extra effects that add value
- Possible Side Effects
- Food And Drug Interactions
- Black Cialis vs. Viagra vs. Levitra vs. other treatments
- Safety Note On Cialis Black
- Is Cialis Black right for me? Cialis alternative that works for you
Generic Cialis Black 800mg is a drug indicated for the use in males with severely compromised erectile function. Cialis Black features a maximally enhanced formula that encompasses both a chemically active ingredient tadalafil used in the original Cialis, and time-tested herbal ingredients that provide additional benefits in health outcomes. Cialis Black improves sexual performance by increasing endurance, stamina and amplifying libido. This is achieved thanks to the presence of natural herbal aphrodisiacs in the drug’s composition.
Thanks to the presence of herbal components that intensify the sex drive, Cialis Black is especially beneficial for individuals with decreased libido and those in whom erectile difficulty is conditioned by psychological reasons and internal blocks associated with weak sexual constitution. Such lack of sexual desire can be linked to congenital or acquired physical and mental diseases (hormonal changes, psychological blocks, severe stress etc.).
Applications of Cialis Black
Cialis Black 800 is used to treat erectile dysfunction (ED) in its advanced stages (which is defined as complete inability to achieve penile hardness for an intravaginal penetration), aggravated by a decrease in libido and / or stamina. The herbs used in Cialis Black revive sexual energy and stimulate sexual desire, unlike the conventional pills that only contain tadalafil as the main and the only medicinal ingredient.
Its unique composition renders Cialis Black an exclusive status of a sex health pill with a special libido-boosting status. The drug’s advantages are reinforced by a safe combination of ingredients that jointly provide erectile and sensual intensification. Cialis Black is purposefully developed to benefit patients who require an improving agent for the sexual ability as well as the capacity.
The utility of Cialis Black lies with the medication’s proven safety, whereas combining herbal and othe existing aphrodisiacs with pharmaceutical drugs for erectile function always poses risks of adverse reactions linked to pharmacological incompatibility.
Thanks to this unprecedented combination, Cialis Black 800mg effectively addresses psychological ED, which otherwise displays a lower percent of curability. This is why Cialis Black addresses a broader spectrum of ED cases than the original tadalafil pills that appear to be effective both organic impotence rather than psychogenic.
How To Use
The drug can be taken “as needed” from 30 minutes to 12 hours before sexual activity. The recommended dose is one tabled. Do not increase the dose in the case of ineffectiveness, since Cialis Black contains the maximal dose of tadalafil allowed for ingestion within 24 hours’ timespan.
Contraindications
Speaking on the metabolic cycle NO / cGMP, tadalafil potentiates the hypotensive effect of nitrates and its administration is contraindicated in patients who are taking nitrates in any pharmaceutical formulation. It is also contraindicated in patients with a recent history of stroke and heart attack, and for possible disturbances to vision, even in patients with degenerative retinal diseases such as retinitis pigmentosa. The drug should not be used in patients with severe hepatic impairment.
Health Effects And Benefits
Tadalafil is the second reversible selective inhibitor of phosphodiesterase type 5 (additional info about PDE5 inhibitors: mycanadianpharmacyrx.com/pde5-inhibitors). The phosphodiesterase (PDE) are a group of enzymes involved in numerous cellular functions. The PDE5 is present in high concentration in the smooth muscles of the corpus spongiosum of the penis where the enzyme promotes the degradation of cyclic guanosine monophosphate (cGMP). The increase in cGMP leads to a relaxation of the smooth muscle cells – vasodilation – which allows an increase of blood flow in the cavernous bodies of the penis, is the basis of the mechanism of erection.
The physiological mechanism of erection, after sexual stimulation, is mediated by the release of nitric oxide (NO) at the level of the corpus spongiosum by postsynaptic parasympathetic neurons and, to a lesser extent, by endothelial cells; the nitrogen oxide rapidly diffuses and stimulates the guanylate cyclase in smooth muscle cells that surround the sinusoids of the corpus spongiosum, increasing the cGMP content that causes their relaxation.
Tadalafil potentiates the action of cGMP, which is the reason why its effectiveness is manifested only when, as a result of sexual arousal, the central type or reflection, increases the production of cGMP in penile tissues: then its operation is subordinate to the integrity sexual interest, with the whole cascade of biochemical events that are interrelated. The participation of the partners to the sexual act is becoming a determining factor. If there is no excitement and emotional engagement, the drug has no effect. Tadalafil does not increase the frequency and intensity of sexual desire.
Tadalafil has a different chemical structure from sildenafil and, unlike the latter, in vitro shows poor activity against other PDE isoforms, as PDE6 present in the retina.
After oral administration, reaching peak plasma concentrations after about two hours, it is metabolized by cytochrome P450 and is eliminated as inactive metabolites mainly in the faeces and to a lesser extent in the urine. The kinetic profile of tadalafil differs from that of sildenafil especially for the longer half-life, 17.5 hours vs. 3.8 hours. Consequently the onset of action is delayed compared to sildenafil but much more protracted. Studies show significant activity even 24 hours after taking the drug.
Extra effects that add value
Whatever the origin, erectile dysfunction can be treated effectively. Yet it is necessary to know the cause. Before considering any treatment, the subject should be approached with a doctor to remove any doubts about an underlying condition.
The classical investigation includes an examination of the patient’s lifestyle and medical history, as well as a clinical examination. In particular, the doctor will review events that may affect erectile function (stress, anxiety, etc.), common medications, alcohol and tobacco use, and recreational drug use.
The clinical examination consists of taking blood pressure and examining the pulse in the groin, an examination of the genitals and a neurological examination. Finally a blood test will verify the levels of sugar, cholesterol and hormones in the blood. The physician can thus refer the patient to a suitable specialist, psychologist, sexologist, urologist or andrologist, depending on the pathology identified.
Frustration related to male impotence, for one instance, can be addressed with Cialis Black 800 thanks to its enhanced formula featuring herbal components with antidepressant qualities. Since erectile dysfunction has a significant impact on the morale of suffering men, it is interesting to consult a therapist, even if it has an organic cause. Indeed, a vicious circle, linked to anxiety, can settle, possibly disrupting the proper functioning of the treatment put in place. Consultation with a psychologist or sexologist allows for dialogue and overcoming the anxieties that can arise in men with erectile dysfunction and lessen the impact on their lives, whether it is fear of being rejected or abandoned by his or her partner, the loss of self-confidence. If a relationship between an event and the onset of erection problems, or a conjugal problem, is identified, a psychological follow-up may be offered to the patient. Five approaches are particularly used in sex therapy:
- Cognitive-behavioral therapy, which, by detecting and defusing negative thoughts about sexuality, will help break the vicious circle;
- The systemic approach to studying the interaction of spouses or partners and their effect on their sexual life is what is often referred to as ‘couple therapy’;
- The analytical approach, to try to solve internal conflicts at the origin of erectile dysfunction by analyzing the imagination and the erotic fantasies;
- The existential approach, to help the person in his perception of his sexual difficulties and to know better the sexo-physical approach, which will take into account the inseparable bonds body – emotions – intellect, and to restore a satisfactory sexuality both on the personal level than relational.
These therapies can of course be combined with drug therapy like Cialis Black 800; thanks to the additional ingredients used in Chinese traditional medicine for relaxation, libido enhancement and confidence boost.
Possible Side Effects
Side effects of tadalafil are similar to those of sildenafil: the most frequently reported during the studies were, in descending order, headache, indigestion, back pain, myalgia, flushing of the face, nasal congestion, diarrhea. At the moment the data are insufficient to assess the long-term side effects, and in groups of patients at high cardiovascular risk.
Headache, flushing and dyspepsia are closely related to the mechanism of pharmacological inhibition of type 5 phosphodiesterase isoenzyme. This fact is not only in the corpus spongiosum, although predominant here, and be effective also in other metabolic pathways . The tadalafil, thanks to the greater selectivity for PDE5 with respect to PDE6 (found in high concentration in the retinal cells), seems to cause less easily, compared to the sildenafil, vision abnormalities.
Like other inhibitors of PDE5, tadalafil also has the potential of lowering your blood pressure, which could be a problem in patients being treated with antihypertensives.
During postmarketing surveillance, they have come to the US and Canadian health authorities some reports of non-arteritic anterior ischemic optic neuropathy (NAION) occurred in patients taking inhibitors of phosphodiesterase 5 (PDE5) inhibitors for the treatment of erectile dysfunction. The NAION is due to a lack of blood flow to the optic nerve and results in a sudden loss, painless, partial or complete, of the view, in one or both eyes. Although some patients may have a functional recovery over time, in others the damage is irreversible. Patients who have had an episode of NAION are at greater risk of experiencing a second episode in the other eye.
Among the factors predisposing to the onset of NAION there are included:
- age older than 50 years
- the presence of coronary artery disease
- a high pressure
- high cholesterol
- diabetes
- smoking
These risk factors play an important role in the onset of erectile dysfunction.
Most of the reports of NAION associated with the use of PDE5 inhibitors sildenafil concerns (38 of the 43 cases reported to the FDA and 2 were reports to the Canadian authorities) and, respectively, 4 recommendations are related to tadalafil and vardenafil. The majority of patients had one or more of vascular risk factors for NAION.
The small number of reported events compared to the large number of users of PDE5 inhibitors and the fact that most of the reports concern patients with a risk profile similar to patients diagnosed with NAION but that does not make use of these drugs, make it difficult at the time, with security to establish a causal link between the use of PDE5 inhibitors and the appearance of this disorder. However, some factors, such as the temporal causality between the drug and the onset of NAION in some of the reported cases and the presence of recurrent ocular symptoms consistent with NAION in other cases, make this plausible association.
Looking forward to better define the safety of use of PDE5 inhibitors, health authorities recommend to:
- Advise patients to immediately stop taking Cialis Black if there were to be a sudden reduction of vision in one or both eyes, and immediately report the event;
- Discuss with patients who have a history of NAION the possible increased risk of optic neuropathy associated with the use of these drugs and to evaluate with them the opportunity to use.
Food And Drug Interactions
It is possible for Cialis Black to have interactions with any drug inducer or inhibitor of CYP3A4. There are no interactions with food and alcohol. Cialis Black should not be taken simultaneously with anti-hypertensive drugs and chest pain (angina) drugs that contain nitrates. Drugs that have blood-lowering pressure as a side effect should not be used alongside with Cialis Black, since such effects will be reinforced in an uncontrolled manner by the hypotensive action of tadalafil.
Black Cialis 800 vs. Viagra vs. Levitra vs. other treatments
Black Cialis 800 is a generic tadalafil pill related to the family of PDE5 inhibitors. Since the late 1990s, the most popular oral treatments are the phosphodiesterase type 5 – sildenafil (Viagra), vardenafil (Levitra) and tadalafil (Cialis) inhibitors.
These drugs, sold by prescription, have the effect of relaxing the muscles of the arteries of the penis to allow the influx of blood into the penis and thus an erection. Sexual stimulation is necessary for them to act. There are various dosages and durations of action. These drugs are effective in 70% of cases, but contraindications are possible, especially in case of drug interactions and for men with heart problems.
In any case it is essential to obtain a medical prescription from a doctor to ensure you buy a treatment without risk to your health. Since recently, cheaper ED drugs are available online. The medical consultation, instead of taking place in the office of your doctor, is carried out by medical questionnaire via the internet.
Depending on their doctor’s diagnosis, you get an approved medical prescription that you will only need to present in your pharmacy to buy your erectile dysfunction treatment. And for those who do not want to go to a pharmacy, you can buy the treatment directly from their partner pharmacy.
In cases where PDE5 is ineffective or is contraindicated, the physician may prescribe vasoactive substances, for example, alprostadil (Caverject) that the patient self-administers. This prescription treatment involves injecting a drug at the base or side of the penis before intercourse. These drugs, such as PDE5, allow the relaxation of the muscles of the arteries of the penis, which increases the influx of blood, with the difference that a sexual stimulation is not necessary. The erection is reached in 5 to 20 minutes and lasts about 1 hour. Although not very popular because of its mode of administration, this treatment is effective in 85% of men.
An alternative to the administration of oral or injection drugs, ED creams, are now available. Presented in the form of a cream to be applied to the penis, it acts in the same way as the previous drugs, but its action is faster and involves less risk of drug interactions.
When previous treatments do not work or are not suitable, for example if the nerves have been damaged due to surgery or injury, consideration may be given to the use of certain mechanical devices such as penile implants that require surgery in order to permanently implant flexible inflatable mechanism allowing the erection of the penis by means of a system linked to a pump inflatable by hand.
If erectile dysfunction is caused by hypogonadism, hormone treatment with testosterone may be considered. Alternative medicines (homeopathy, phytotherapy, acu puncture) have not been proven in the treatment of erectile dysfunction.
Safety Note
Speaking on the metabolic cycle NO / cGMP, tadalafil potentiates the hypotensive effect of nitrates and its administration is contraindicated in patients who are taking nitrates in any pharmaceutical formulation.
Patients with known allergies should report them to their prescriber before proceeding with Cialis Black therapy.
Cialis Black contains a maximal dose of tadalafil, which makes its use contraindicated in patients with liver, kidney, stomach and heart problems, as well as persons belonging to the geriatric group of patients.
Cialis alternative that works for you
You should be warned that Cialis Black is a very strong medication that goes along with, apart from the obvious potency problems, great health condition. We recommend always starting with the minimal dose and gradually work up your way to higher dosages as needed, but always under professional supervision. My Canadian Pharmacy has developed a starter kit containing the three most popular ED drugs: Viagra, Cialis and Levitra. Which pills that work best for each person are individual and doctors often recommend trying out. With our discreet startup package, you now have the opportunity to try to find out which potency is best for you.
This article (mycanadianpharmacyrx.com/generic-cialis) was prepared by a professional team of My Canadian Pharmacy to provide you with the information about Cialis. We will tell you how to use the drug, its contradictions and side effects, and what other customers think about it. Our pharmacy offers a large selection of medication and delivers them right to your door. Before buying Cialis online on the website, consult your physician so he or she could prescribe you the right dose of the drug.
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Who can order Classic ED Pack? Men over the age of 18 who experience problems with achieving or retaining erection can use all drugs included in the starter Classic ED Pack.
It is possible that you will be denied treatment if you have heart problems, have had a heart attack or stroke or if you have liver impairment. The medicines included in the Classic ED Pack lower your blood pressure and should not be used if you suffer from low blood pressure. The starter ED pack is also not recommended if you are using any medicines containing nitrates. Be sure to tell your medical history and medical history in our consultation so that our doctors decide if our starter kit is appropriate for you.
As with many other prescription drugs, you may experience some side effects after taking one of these tablets. The side effects are usually mild and very short-lived. The side effects reported include facial redness, headache, nausea and dizziness.
If you are likely to experience any side effects, it may be helpful to decide which pill will best suit you for a longer period than 4 tablets. You can read more about the side effects of the different treatments under their respective product page.
It is important that you read the package leaflet on the respective medicines. You should not overdose, if you have taken Viagra or Levitra, wait at least 24 hours before taking a new tablet. If you have taken a Cialis, you should wait at least 36 hours before taking the next dose. Read more about the pills below their respective product page before use.