Generic Viagra or Stendra: Which Works Better?
If you are diagnosed with erectile dysfunction, don’t think that your sexual life is coming to an end. You are not alone, as ED is becoming an increasingly common medical condition even among younger men, and pharmaceutical developers are doing their best to come up with an ED drug formula that is the most effective, yet causes as few side effects as possible. When you have to choose a certain medication to address your erectile difficulties, you are faced with a rather vast variety of medicines specifically designed to enable an erection. You can buy Viagra, Levitra, Cialis, and Stendra – the newest product on the market. Is it up to par with the “traditional” solution (Viagra), or is it even better or perhaps worse? If you’re interested in finding out, keep reading, and your doubts will probably be resolved in a matter of minutes.
Why Would I Want to Choose Generic Viagra?
Viagra (learn more about this medication) has been on the ED medications market for a really long time (almost two decades). In that time, it has become the ultimate way to treat ED for many men. They like it because it is effective (more than 80% of Viagra users claim that it works for them), safe (serious side effects are infrequent, and mild side effects are easy to tolerate) and reliable, since it has already been used by generations of men. Viagra works as a PDE-5 (a certain enzyme in the male body) inhibitor, so when a man takes a Viagra pill, blood flow to his penis is increased, which makes an erection possible if the man is sexually stimulated.
Generally, Viagra starts working in about 30 minutes after intake, although patients are advised to take it one hour prior to intercourse, as, in some men, it works slower than in others due to different metabolism rates. Eating fatty foods before or while taking Viagra is likely to slow the pill down, as it complicates its absorption through the stomach. The effect of Viagra normally lasts for about four hours after it first kicks in. A rare side effect of Viagra (as well as other ED medications) is its ability to cause priapism in some men. Priapism is a painful or prolonged (lasting more than four hours) erection. If you ever happen to experience such symptoms, do not hesitate to seek professional medical help because leaving priapism unaddressed could lead to permanent damage to the penis.
All in all, Viagra is a well-established medication for treating ED, which delivers the promised result in the majority of cases. In addition, its long-term presence on the market means that it has been successfully used by an impressive number of people, which proves its reliability and safety.
Viagra vs. generic Viagra. If you want to make a comparison and choose the most beneficial option for your needs, read more here: http://www.mycanadianpharmacyrx.com/brand-vs-generic-viagra.html
Composition of Avanafil (Stendra)
Avanafil is the active agent that makes up the main part of Spedra. For the metabolic reaction to take place, excipients accompany the avanafil in Spedra tablets:
- Mannitol
- Fumaric acid
- Hydroxypropylcellulose
- Low-substituted hydroxypropylcellulose
- Calcium carbonate
- Magnesium stearate
- Yellow iron oxide (E172)
Is Stendra Any Better Than Generic Viagra?
Unlike the famous blue pill, Stendra has only been around since 2012. Stendra relies on the same biochemical effect as the one provided by most other ED medications: it inhibits the PDE5 enzyme and increases the blood flow to the penis. However, all ED drugs rely on different components to achieve the desired effect, so some particular features vary from one medication to another.
Stendra is one of the newest drugs on the market, so the research on it is (as of now) quite limited. However, the results of clinical trials show that Stendra is a rather effective pharmaceutical. During trials, participants were divided into two groups: those who received a dose of Stendra, and those who took a placebo. It turned out that about 80% of patients with general erectile dysfunction were able to have a satisfactory sexual experience, as opposed to only half of the men who got a placebo. Among patients with ED caused by diabetes, the success rate of Stendra was about 65%, compared with slightly more than 40% in those who received a placebo. A successive trial focused on more than 600 men who were to use Stendra thirty minutes prior to attempting sexual intercourse for twelve weeks. The prescribed dosages varied depending on every individual patient, and the participants were free to eat any types of food and drink alcohol before taking Stendra. About 70% of attempts to have a sexual intercourse that were undertaken during the study were successful, while the control group of men who received a placebo pill didn’t show great results, as only one-quarter of them were able to develop and maintain an erection.
As you can see, Stendra is almost equally effective compared to Viagra and other ED medications on the market. It did not show any results that would make it stand out among its competitors, particularly Viagra. What might make you want to switch to Stendra from Viagra then? Consider this: during the studies, most men reported that Stendra started working in as little as fifteen minutes. In some patients, the pill needed about thirty minutes to deliver its effect, while for Viagra, it is the minimum amount of time required for the pill to be absorbed and start working. Consequently, Stendra works twice as quickly as Viagra. In addition, clinical trials have shown that Stendra can be taken with any amount of food and alcohol, as they do not influence the onset of the drug’s effect. On the other hand, Viagra performs better if taken on an empty stomach, and consuming alcohol with it increases the risk of developing side effects, including severe ones. Additional research has shown that in some men, Stendra can keep working even six hours after the medication was taken. The standard duration of Viagra’s effect is four hours, with some users reporting up to five hours of being able to develop and maintain an erection.
What about side effects then? The side effects of Stendra are fairly similar to those of the “little blue pill”. The mild ones include headaches, flushing, and runny nose for both drugs. In rare cases, both Stendra and Viagra may cause sudden vision or hearing loss, as well as priapism. Other less common side effects of both medications are the following: back or chest pain, diarrhea, dizziness, rashes, and muscle aches. However, the reported rate of occurring side effects in Stendra is lower compared to Viagra.
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Bottom Line
If you are a long-term Viagra user, you might want to consider switching to Stendra temporarily to see if it works better for you. If you are new to the ED drugs market and have to choose your first ED medication, you can opt for Viagra if you prefer reliability and a good reputation, or you can step off the beaten track and try Stendra – a new and promising medication with the additional benefits of a quick effect as well as unlimited food and alcohol consumption.
How to buy Viagra and Stendra online? Common questions and answers by Canadian Pharmacy
We often get questions about how to buy Viagra or Stendra online. Here we answer some of the most common questions about how to order drugs using the services of Canadian Pharmacy.
The first step is to look for the drug you are interested in ordering. It is a good sign if the drugstore online you seek to place an order with provides free consultation online. In this way, you win twice: by getting a proof that the pharmacy in question is ethical, and by saving your time, money and energy – and for some individuals, the embarrassment of having to have an open face to face discussion of their intimate problem with the specialist. You will then receive a free online consultation, where you will be able to answer any questions in a questionnaire. Your answers then form the basis of the medical assessment that one of our doctors will do. If the doctor approves the treatment, a prescription for the drug will be issued. This prescription will be sent to you with your medicine.
Usage restrictions (contraindications) of Viagra and Stendra
A few factors strongly suggest taking Stendra. The medication should not be used if an allergy to sildenafil or avanafil is known. If medicines that release nitrous oxide, such as amyInitrite or nitroglycerin, or drugs for chest pain, are taken, Viagra or Stendra must not be used.
The potency also enhances the effect of concomitantly injected drugs and can also reduce blood pressure drastically. In case of ingestion of drugs against AIDS or HIV, such as ritonavir, saquinavir, atazanavir or nelfinavir, neither Viagra nor Stendra can be used.
Concomitant use of PDE5 inhibitors and anti-fungal drugs, such as ketoconazole or voriconazole, as well as antibiotics to treat bacterial infections should be avoided. If a serious heart disease is present, a stroke or heart attack has occurred during the past six months, if it is likely that you suffer from heart disease, if your blood pressure is abnormally low or high, if liver or kidney problems occur, chest pain occurs during sexual intercourse or If there are serious eye problems in the family, Viagra and Stendra should not be taken.
If a physical disorder affects the shape of the penis, such as a swollen body fibrosis, a doctor or pharmacist should be advised before taking either of the drugs. The taking of Stendra can trigger dizziness and an abnormal feeling and affect the ability to drive and use machines. If dizziness occurs, it is recommended that you do not drive the traffic at all. Even machines or tools cannot be used. Currently, there are no reliable data on the use of Stendra and its effects on fertility or infertility. However, in patients, no adverse effect on sperm has been found until further notice.
For all sorts of interesting facts about the drug and how to use it go to the article written by our specialists. Canadian pharmacy decided to elaborate on many interesting aspects of the drug and its possible medical applications: http://www.mycanadianpharmacyrx.com/generic-stendra-avanafil.
Canadian Pharmacy experts tell how to minimize Viagra and Stendra side effects
Viagra, Stendra and other PDE5 inhibitors should always be taken only in consultation with a doctor. The drug should not be taken more than once a day. If the dose is too strong or too weak, a dose adjustment may be made under medical supervision or possible treatment options discussed. Viagra and Stendra should be taken about half an hour before intercourse so that the medicine can work properly. If you accidentally take a higher dose of Stendra, a doctor must be informed accordingly.
Occasionally, multiple drug interactions occur or are taken simultaneously. As a result, the effect of the drug can be changed. In consultation with a doctor or pharmacist, it should be established before an individual risk of interactions exists.
Due to its vasodilating effect, both Viagra and Stendra can enhance the reduction in blood pressure caused by drugs from the group of alpha sympatholytic and calcium antagonists. Concomitant treatment may lead to dizziness, fatigue, and fainting. PDE5 inhibitors Stendra and Viagra diminish or annihilate the effects of the following medications: carbamazepine, phenobarbital, rifampicin, efavirenz, bosentan.
The mode of action of Viagra and Stendra is based on an easy interaction of enzymes. Therefore, the use of inhibitors of these enzymes is not possible. These drugs include: antivirals (Atazanavir, Indinavir, Nelfinavir, Ritonavir), antibiotics (Clarithromycin, Telithromycin), antidepressants (Nefazodone) and antifungals (Itraconazole, Ketoconazole)
The enzymes of grapefruit can also interfere with the effect of potency. They slow down the decomposition of the drug and may therefore increase the risk of side effects. The intake of PDE5 inhibitors is therefore best done with water, as the drug in this case is not affected. The risk of sudden drop in blood pressure is increased by the consumption of alcohol. For safety reasons, avanafil should not be taken concurrently with alcoholic beverages. Interactions can be life threatening and must be taken seriously. If interactions with other drugs, not listed here, are determined, a doctor should be consulted.
Safety rules common for Viagra and Stendra
Both Viagra and Stendra are used to treat ED (erectile dysfunction) in men. The effect is based on the active ingredients sildenafil and avanafil, which are PDE5 inhibitors. Although the drugs are generally tolerated well, side effects may occur when taking either.
Like all medicines, Stendra and Viagra both can also cause side effects, but not everybody gets them. If serious side effects occur after taking Stendra, you must discontinue use of the medicine immediately and contact a doctor. Serious side effects include erections that are not lost. If an erection lasts longer than four hours, this condition must be treated immediately, as the erectile function may be permanently damaged otherwise.
A sudden deterioration of vision of one or both eyes or total vision loss can occur as a serious side effect. Similarly, serious side effects that affect your hearing are possible: ear piercing, a diffuse noise or total loss of hearing show that you should make a doctor’s visit as soon as possible. Among the most common side effects are headache, redness, and nasal congestion. There are occasional reports of dizziness, sinus pain, blurred vision, palpitation, indigestion, nausea and stomach discomfort.
Read also our comparison: Stendra vs Viagra vs Cialis
Muscle tension, backache, fatigue, increased heart rate, elevated amount of liver enzymes and abnormal ECG may also occur occasionally when taking Viagra or Stendra. In rare cases you suffer from symptoms such as flu, insomnia, premature ejaculation, angina pectoris, tachycardia, dry mouth, stomach inflammation, rash, frequent urination, itching, blood in urine, fluid retention in arms and weight gain. All these side effects and other side effects not listed here must be taken seriously. Stendra should definitely not be taken if side effects occur for a long time.
Stendra FAQ answered by Canadian Pharmacy
Q: What is Stendra?
A: Stendra is used to treat impotence. Stendra belongs to a new generation of pills; the treatment was approved for distribution in Europe in 2013. The pill is prescription and contains the active substance avanafil. In order for Stendra to give effect, sexual stimulation is required.
Q: What is Stendra medical use?
A: Stendra is a potent medicine used to treat erectile dysfunction in adult men. It is an alternative to other potential agents such as Viagra, Cialis and Levitra. Stendra is available in three different doses: 50, 100 and 200mg. It seems faster than many other potential agents and the effect lasts for up to 6 hours. Because the drug causes fewer side effects than other preparations, it is an excellent option for those who experience side effects when using other anti-impotence drugs.
Q: How long does it take for Stendra to work?
A: Avanafil starts working very quickly, its actions on the organism usually begin a few minutes after taking, about 15 minutes. The maximum plasma concentrations caused by Spedra peak after 30 minutes of taking the treatment if it was taken on an empty stomach. If avanafil has been taken with a meal, the peak efficacy of Spedra can be up to 1 hour.
If avanafil is taken with a high-fat meal, the overall efficacy of the treatment will be reduced by 20%, the duration of action will be shorter, and the effects on PDE5 can start at 1:25 after taking, on average. Changes in Cmax (treatment efficacy) and Tmax (peak treatment efficacy) will not affect the clinical effects of treatment.
Q: For how long is Stendra active in the body?
A: After swallowing, avanafil dissolves rapidly in the body and has a maximum action time of 30 min. Its terminal half-life is about 7 to 15 hours. Excretion of avanafil occurs in the faeces at 63%, as well as in the urine at 21%. Stendra is an excellent alternative when other potential agents do not work contains the PDE5 inhibitor avanafil that increases blood flow to the penis. Stendra works within 15 minutes of effect for up to 6 hours
Q: How is avanafil contained in Stendra eliminated from the body?
The pharmacokinetic properties of avanafil are dose-related over the recommended dose range. The active agent and excipients are removed by hepatic metabolism (CYP3A4), which is associated with a plasma increase in avanafil. Avanafil is eliminated by minor (CYP2C9) and major (CYP3A4) hepatic microsomes; the parent compound contains 23% M4 metabolite and 29% M16 metabolite.
The metabolite M4 contributes to 4% of the pharmacological activity; its characteristics resemble the avanafil molecule, with an in vitro inhibitory potency of phosphodiesterase type 5 corresponding to 18% of the potency of avanafil; as well as a selectivity profile for similar PDE5. The metabolite M16 acts as a secondary metabolite by being inactive directly on PDE5.
Q: What dosages of Stendra are available at Canadian Pharmacy Online?
A: Stendra is an effective pills with fast effect. Stendra contains the active substance avanafil which had a clinically proven effect in many men. Stendra is available at doses 50, 100 and 200mg at Canadian Pharmacy www.mycanadianpharmacyrx.com.
Q: What are the advantages of Stendra?
A: One of the fastest-acting potent pills in the market Effect for up to 6 hours Less side effects than other potential agents Do not affect hearing or sight unlike other potassium pills
Q: Are there any results of clinical studies on Stendra efficacy and safety?
A: In clinical trials conducted on Stendra’s active substance avanafil, the drug has been shown to have a positive effect on the erectile function of men suffering from impaired erectile dysfunction. In four studies, a total of 1,774 patients received avanafil in the three different doses (50mg, 100mg and 200mg). In the general group, the average number of successful intercourse was approximately 47 percent for those treated with 50mg avanafil, 58 percent for those taking 100mg, and 59 percent for those receiving 200mg avanafil. The corresponding figure for patients in the placebo group was 28 percent.
In the group where the participants had diabetes mellitus type 1 or 2, the mean rate of successful intercourse was approximately 34 and 40 percent respectively for those treated with 100mg and 200mg of the active substance respectively. The same number for patients in the placebo group was only 9 percent. The overall result of the studies was that avanafil showed a statistically significant improvement in the erectile function.
Q: How does Stendra work?
A: Stendra contains the active substance avanafil in three different doses. Avanafil increases blood supply to the erectile tissue, which makes it easier to achieve and maintain erection. Stendra does not affect your sexual desire but improves your erection when you are sexually excited. The majority of men get a harder and longer term erection. If this is not achieved, the dose can be increased to Stendra 100mg or 200mg.
The pill contains avanafil, mannitol, fumaric acid, hydroxypropylcellulose, calcium and magnesium. If you are allergic to any of these substances, do not use Stendra. For a full content declaration, read the package leaflet.
Q: Who can use the treatment?
A: Men over the age of 18 who suffer from impotence can use Stendra. There are those who do not use treatment, including people who use drugs for chest pain or nitrate forms. See the package leaflet for more information.
Q: What is my dose for intake of Stendra?
Stendra contains the active substance avanafil in three different doses. Avanafil increases blood supply to the erectile tissue, which makes it easier to achieve and maintain erection. Stendra does not affect your sexual desire but improves your erection when you are sexually excited. The majority of men get a harder and longer term erection. If this is not achieved, the dose may be increased to Stendra 100mg or 200mg.
A: The pill contains avanafil, mannitol, fumaric acid, hydroxypropylcellulose, calcium and magnesium. If you are allergic to any of these substances, do not use Stendra. For a full content declaration, read the package leaflet.
Q: What are the side effects of Stendra?
A: Few side effects have been noted in clinical trials of Stendra, but as with other treatments for erectile dysfunction, the most common side effects are redness, headache, clogged nose and stomach problems. These are transient. If you experience side effects you can try to reduce a dose as this tends to remedy the side effects.
Q: What are the known Stendra interactions with other drugs?
A: Stendra’s active substance avanafil has been shown to enhance the effect of nitrate containing drugs. Therefore, the drug should not be used in patients using organic nitrate or nitric oxide donors, such as amyl nitrite. Other medicines and the like where interactions can occur are as follows: medicinal products with antihypertensive effect Alfa-blockers such as tamsulosin and doxazosin CYP3A4 inhibitory drugs such as erythromycin, itraconazole, voriconazole, nefazodone, clarithromycin, saquinavir, indinavir, nelfinavir, atazanavir and telithromycin Riociguat
Q: Is Stendra alcohol compatible?
A: It is also good to know that the use of alcohol with avanafil may potentially increase the risk of low blood pressure and increased heart rate. It can lead to dizziness, headache or palpitation (that you feel the heartbeat). Alcohol can also have a negative effect on your erectile function.
Q: Why does the instruction warn against the simultaneous intake of grapefruit and Stendra?
A: It is also true that grapefruit juice should not be consumed for at least 24 hours before dosing of Stendra, for the reason that grapefruit may have a negative effect on the effect of the drug.
Q: Should I consult my doctor for Stendra prescription?
A: You absolutely should. The person who is best suited to assess whether it is safe for you to use Stendra or not, and if there is a risk of interactions between the different medicines you are using, your doctor is. It is therefore important that you consult this if you are not sure what is applicable to you.
Q: What are Stendra contraindications?
Stendra is contraindicated to people who are hypersensitive to the active substance avanafil or any of its excipients. You should also not use Stendra with people using organic nitrate drugs or nitric oxide donors (such as amyl nitrite). The same applies to the use of other PDE5 inhibitors as other medicinal products containing avanafil. Even guanylate cyclase stimulators such as riociguate are contraindicated for simultaneous use as Stendra. The reason for this is that the combination may result in symptomatic hypotension. If you have previously had a cardiovascular disease, if so, the doctor should pre-prescribe the risk of heart problems that sexual activity may involve. Other situations when you should not use Stendra include:
You have had stroke, heart attack or life threatening cardiac arrhythmias during the past six months. You have abnormally low blood pressure at rest or high blood pressure. You have unstable angina or heart failure. Your liver function is severely impaired. Your kidney function is severely impaired. You have lost sight of an eye due to non-arterial front ischemic optic neuropathy You have congenital degenerative retinopathy You use CYP3A4 inhibitors such as ketoconazole, atazanavir, ritonavir, clarithromycin, itraconazole, indinavir, nefazodone, nelfinavir, sakvinavir or telithromycin.
