Generic Celebrex (Celecoxib) 100/200mg: Celebrex for Pain, Applications,  Dosage And Ingredients, Alternative, Combination with Other Drugs, Side Effects, For Back Pain And Arthritis, Celebrex And Bleeding, Celebrex Vs. Mobic, Celebrex Vs. Ibuprofen

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Celebrex

What Is Celebrex (Celecoxib)?

Celebrex stands out among the newest non-steroidal anti-inflammatory agents distinguishing themselves by the high degree of intensity in regards to blocking of pain syndrome. It belongs to the pharmacological group of substances which take the selective activity in relation to stimulation of COX production. These biological substances decrease susceptibility of prostaglandins to antibodies and granule cells contents. Thus, Celebrex intake contributes to temperature decrease during inflammatory processes including reduction of hyperemia, edema, and local hyperemia in diseased articulations and vertebral spine. This medication may be applied in the capacity of the main medicine in all cases when it is required to neutralize the component of inflammatory influence. Due to edema blockage, the effect of elimination of painful condition occurs. Celebrex is issued in the form of capsules. Active substance of the drug, celecoxib is located inside the gelatinous coating which gets absorbed in small intestine.

Celebrex for Pain

Celebrex for Pain

Non-steroidal anti-inflammatory action of the medicine is based on its ability to inhibit the production of inflammatory agents. The leading role in pharmacokinetics belongs to regulation mechanism of diverse prostaglandins production. In case of imbalance, these substances may be produced in bid quantity. They cause large blood flow (which contains blast cells, eosinophil granulocytes, leukocytes) in the location of inflammatory reaction. All these elements form stagnant edema and a basis for pain syndrome development. Resulting from specific inflammatory reaction and regardless of large blood supply through tiny capillaries, there is a deficit of blood flow to damaged tissues. This condition slows down the reproduction process of sound cells and restoration of a man.

Absorption of active substance occurs from small intestine. In 20 minutes after the intake of medicine there is a first reaction in the form of pain and edema level reduction. Maximal concentration in blood is achieved within 40-50 minutes. The clearance time is around 12 hours. It is worth mentioning that Celebrex intake along with fat or challenging food decreases the drug’s efficiency considerably. Therefore, the tablets should be taken fasted or in 1,5 hours after food acceptance.

Celebrex Application

Celebrex is indicative in the following cases:

  • Ostheoarthrosis;
  • Rheumatoid arthritis;
  • Pain syndrome of diverse etiology (including post-surgical, toothache, menstrual colic, muscular aches).

Celebrex Dosage

Celebrex DosageThe medication should be taken regardless of food acceptance without chewing and drinking with water. Since the risk of possible cardio-vascular complications may grow with dosage increase and intake duration, Celebrex should be prescribed by short courses and minimum doses. Maximal daily dosage in case of long-term intake is 400mg.

In case of expectant treatment of ostheoarthrosis the maximal daily dosage is 200mg once or twice over a day.

In case of expectant treatment of rheumatoid arthritis the recommended dosage makes 100mg or 200mg twice a day.

In case of expectant treatment of ankylosing spondylitis maximal daily dosage is 200mg per day once or twice over. Some patients reported the efficiency of the drug in the dosage of 400mg twice a day.

In case of pain management and primary dysmenorrhea the initial recommended dose is 400mg with subsequent intake of additional dose of 200mg in the first day, if required. The following days the recommended dose is equal to 200mg twice a day, if required.

Aged patients do not need the correction of dosage. Anyway, in case a patient with body weight less than 50kg should start treatment with the least recommended dose.

Patients with mild degree of hepatic decompensation do not need the correction of dosage. In case of moderate degree of hepatic decompensation, treatment should be started with minimally recommended dose. There is no experience of the drug usage by patients with severe form of hepatic decompensation.

Patients with impaired kidney function of mild and moderate severity level do not require the correction of dosage. There is no experience of the drug usage by patients with severe form of impaired kidney function.

Patients taking fluconazole (CYP2 C9 inhibitor), should administer Celebrex in minimally recommended dosage. The medicine should be taken with case in combination with other inhibitors of CYP2 C9 isoenzyme.

Celebrex should be taken with case by patients who prove to be poor metabolizers, since this condition may cause accumulation of high concentrations of Celecoxib in blood plasma. These patients must reduce the initially recommended dose in half.

Generic Celebrex Full List of Ingredients

Celebrex is issued in the form of firm gelatinous capsules of white non-transparent color.

  • Active substance: celecoxib.
  • Auxiliary agents: lactose sulphuric monohydrate, sodium lauryl sulfate, povidone, croscarmellose sodium, magnesium stearate.
  • Coating composition: titania, gelatin.
  • Blue ink composition: stick lac, ethanol, isopropanol, butanol, propylene glycol, ammonia, blue dye indigotin.

Celebrex Alternative

The direct analogues of Celebrex are medications which are produced on the base of celecoxib and fall into the pharmacological group of cyclooxygenase (COX) inhibitors.

Celebrex for Back Pain

Back pain is one of the most frequent complaint while consultation by a physician. Treatment modes of acute and chronic pain differ according to occurrence, maintenance, clinical progression, type of pain. In practical terms, it is usually treated by means of drugs from the group of unspecific anti-inflammatory medicines. Occurrence of new medication, Celebrex from Non-steroid anti-inflammatory drugs (NSAIDS) group requires estimation of its clinical efficiency in case of back pains. This drug was developed especially for the long-term intake with minimal (in comparison with non-steroid anti-inflammatory agents) impact on gastro-intestinal tract. Celebrex inhibits selectively cyclo-oxygenase-2 and blocks the production of prostaglandins inducing inflammatory reaction. Celebrex was clinically tested in randomized double-blind trial of the cases of ostheoarthrosis and rheumatoid arthritis. The proved reduction of inflammation and pains was observed. Celebrex intake contributed to considerable reduction of pain intensity, pain influence of life, degree of affective distress resulting in increase of self-control level and quality of patients’ life.

Celebrex for Arthritis

Rheumatoid arthritis’ symptoms are hard to expose at the early stage of disease. Therefore, it cannot be treated completely. The only way of arthritis therapy is relieving of its symptoms and blocking of its progression. Modern methods are aimed at reduction of inflammation, improvement of articulations functions and prevention from incapacitation of patients. Early start of treatment improves the prognosis.

Rheumatoid arthritis therapy lies in application of two types of medications: anti-inflammatory and disease-modifying agents. Anti-inflammatory agents gave a good account of themselves in treatment of arthritis. This group was developed in order to decrease the quantity of side-effects during the long-term intake of the medicine. Celebrex (celecoxib) is one of the most frequently administered drugs for rheumatoid arthritis. Celebrex has nearly the same effectiveness as other NSAIDS. Nevertheless, in comparison with other NSAIDS, it has the minimum quantity of counter-indications and cause side-effects much rarer (especially in gastro-intestinal tract). They may be taken long, within a treatment course from several weeks to several months and years.

Celebrex and Bleeding

Celebrex intake may cause increased risk of thrombosis development including in the area of vital organs (heart and brain). Therefore, the therapy should be conducted with the use of minimally effective doses and within a short period of time. In case Celebrex is taken along with warfarin, this complex therapy may cause bleeding.

Celebrex and Surgery

Celebrex is counter-indicative for postoperative pain treatment in case of coronary bypass surgery performance.

Celebrex and High Blood Pressure

During the whole therapy course by means of Celebrex a patient must monitor arterial blood pressure, since the medication may cause hypertension.

Celebrex and Alcohol

If used along with alcohol, Celebrex may even lead to a lethal outcome of a patient. This medication is developed in a way which absolutely excludes its interaction with ethanol, since the consequences and dangerous.

Celebrex and AlcoholThe effects that may occur in case of combination of Celebrex with alcoholic beverages are as follows:

  • Risk of ulcers and bleeding in gastro-intestinal tract increases considerably. Any alcohol is an irritant for gastro-intestinal tract resulting in the fact that resistance to this medicine becomes very low.
  • High risk of liver damage – the misuse of alcohol may cause the performance of liver and its capability to conduct metabolism of this medicine will suddenly drop. As a result, the active substance gets accumulated in blood causing overdose and hepatic disorder.
  • Cardio-vascular disorders – Celebrex taken along with alcohol will take a double adverse effect on heart. Since these both agents influence it this or that way. If a patient takes the drug after using of alcohol, it may cause problems of the whole cardio-vascular system, such as heart or apoplectic attack.

Nowadays the idea of influence of Celebrex and alcohol combined intake is not perfectly clear. But it may be exactly said that this mixture in organism may be quite dangerous for health. A patient is not to disregard the instruction of Celebrex usage.

Celebrex in Combination with Other Drugs

In case Celebrex is taken along with warfarin, this complex therapy may cause bleeding. Such substances as fluconazole and ketoconazole cause increase of concentration of the active substance, celecoxib in organism, the rate of which grows twice. A patient should avoid the combined usage of Celebrex along with COX-2 blockers, since their combination decreases anti-hypertensive action on organism. It would be wrong to use several medications from the group of non-steroidal anti-inflammatory agents, since this may cause overdose.

Celebrex and Tylenol

These drugs belong to different drug classes. Tylenol doesn’t fall into the group of NSAIDS. So, their combination is not dangerous to combine them.

Celebrex and Tramadol

Celebrex may cause the increase of blood flow and the action of Tramadol. In case your physician prescribes you both medications, you should adjust the dosage and get a frequent monitoring by your attending doctor. You should seek immediate medical attendance in case you experienced any of side-effects affecting your overall condition.

Celebrex and Coumadin

Combined usage of these two medicines may increase the hypo-prothrombinemic impact of Coumadin (its active substance is warfarin). Celecoxib inhibits competitively CYP450 2C9 metabolism, since these both drugs are this isoenzyme substrates. Among aged patients the cases of bleeding disorders or INR increase observed. It may be explained by the fact that these patients being CYP450 2C9 poor metabolizer may have the underlying risk of bleeding disorders or INR increase, since they have the decreased clearance of Celebrex and Coumadin. Such patients must be frequently monitored during this combined therapy.

Celebrex and Aspirin

Celebrex doesn’t substitute acetylsalicylic acid, since it doesn’t have anti-thrombocyte features. Therefore, the intake of Aspirin in case of co-administration with Celebrex should not be ceased. Peptic ulcers occur more often among elderly patients who use the Aspirin along with Celebrex.

Celebrex and Aleve / Naproxen

The concomitant administration of these medications may cause the increase of side-effects. Also, their combined action may result in a severe gastro-intestinal poisonous action, ulcer bleeding and perforation. Before their combined usage, you have to consult your attending doctor in order to adjust dosage and duration of intake.

Celebrex and Eliquis

The interaction of these medications may cause adverse effects, such as bleeding from gums, dark stool, nasal bleeding or bruising. They both decrease the ability of body to produce clots.

Celebrex Black Box

Celebrex is absolutely counter-indicative in the following cases:

  • Liability to bronchial apparatus spasm and bronchial allergy;
  • Peptic ulcer;
  • Any kind of bleeding;
  • Atherosclerotic cardiovascular disease at any stage and of any form;
  • Allergic reactions, such as urticarial fever connected with the intake of acetylsalicylic acid and other NSAIDs;
  • Pronounced hepatic disorder;
  • Pronounced renal disorder;
  • The third trimester of pregnancy;
  • Lactation;
  • Idiosyncrasy to sulphonic-acid amide;
  • Hypersensitivity to Celebrex components;
  • Age under 18 years

Celebrex Sulfa Allergy

Celebrex active substance, celecoxib is a pyrazole derivative substituted by diaryl which contains a substituent of sulfonamide. Thus, Celebrex is counter-indicative to those patients who suffer from pronounced allergies to sulfonamides. Nevertheless, there is not information showing the cross-reactive specificity among sulfonamide-containing medicines. Cross-reactive specificity of such medicines should be premised on scientifically proven data. The up-to-date information has no proof for cross-reactive specificity among sulfonamide drugs, such as Celebrex.

Celebrex Side-Effects

Celebrex Side-EffectOften

  • Generalized reactions: aggravation of allergic disorders, flu-like syndrome, accidental injuries.
  • From the part of cardio-vascular system: peripheral edema.
  • From the part of digestive apparatus: abdominal pain, diarrhea, dyspepsia, flatulency, toothache (alveolar neuralgia).
  • From the part of nervous system: vertigo, muscle tonus increase, insomnia.
  • From the part of urinary system: urinary tract infections.
  • From the part of respiratory system: bronchitis, cough, pharyngitis, rhinitis, sinusitis, upper respiratory infection.
  • From the side of skin integument: rash, itching.

Not often

  • Generalized reactions: face edema.
  • Form the part of hematopoietic system: anemia, ecchymoma, thrombocytopenia.
  • From the part of cardio-vascular system: aggravation of arterial hypertension, increase of arterial blood pressure, heartbeat, tachycardia.
  • From the part of organs of senses: buzzing in ears, blur of vision.
  • From the part of digestive apparatus: vomit.
  • From the part of nervous system: anxiety, drowsiness.
  • From the side of skin integument: baldness, urticarial fever.

Seldom

  • From the part of cardio-vascular system: backward heart failure, ischaemic stroke, myocardial infarction.
  • From the part of digestive apparatus: peptic ulcer, enterobrosia, pancreatitis, liver enzyme activity increase.
  • Allergic reactions: periodic edema, bullous rashes.
  • From the part of nervous system: clouding of consciousness.

Celebrex Abuse

There was not reported any clinical experience of overdose. Healthy volunteers have taken a one-time dosage up to 1200mg and many-time dosage up to 1200mg per day without any clinically significant effects. Therapy is symptomatic. Hemodialysis is ineffective.

Celebrex Vs Mobic / Celebrex Vs Ibuprofen

In case you were diagnosed a rheumatoid arthritis, it is important to know of all types of pain relievers. There are many effective painkillers which may be recommended by your physician. In comparison with disease-modifying anti-rheumatic drugs, these medicines do not slow down articulation anabrosis, but they are helpful in elimination of discomfort.

Mobic and Ibuprofen belong to the group of non-steroidal anti-inflammatory drugs which are used in case of a rheumatoid arthritis. They relieve pain, edema and woodiness efficiently. Their action mode lies in inhibition of synthesis of special enzymes (prostaglandins) causing pain. The key drawback of Mobic and Ibuprofen is their capacity to cause ulcers and bleeding in gastro-intestinal tract. In order to reduce the risk of these complications, a patient should take proton-pump inhibitor which blocks the production of acid in stomach. Mobic and Ibuprofen may also cause indigestion and overall discomfort.

Celebrex belongs to the group of selective non-steroidal anti-inflammatory drugs. These drugs fall into the category of non-steroidal anti-inflammatory drugs but have a lower risk of ulcers and gastro-intestinal bleedings. They relieve pain the same way and degree as non-selective non-steroidal anti-inflammatory drugs. Celebrex is suitable for those patients who have the underlying risk of gastro-intestinal bleedings and need constant administration of painkillers.

This Celebrex Online Guide is created by the research group of Canadian Pharmacy and is strictly informative. Best Regards, MCPrx Team – mycanadianpharmacyrx.com.